Article
NMR structure of Hsp12, a protein induced by and required for dietary restriction-induced lifespan extension in yeast.
PloS one - 1 Jan 2012
Herbert Andrew P, Riesen Michèle, Bloxam Leanne, Kosmidou Effie, Wareing Brian M, Johnson James R, Phelan Marie M, Pennington Stephen R, Lian Lu-Yun, Morgan Alan
Abstract excerpt
Dietary restriction (DR) extends lifespan in yeast, worms, flies and mammals, suggesting that it may act via conserved processes. However, the downstream mechanisms by which DR increases lifespan remain unclear. We used a gel based proteomic strategy to identify proteins whose expression was induced by DR in yeast and thus may correlate with longevity. One protein up-regulated by DR was Hsp12, a small heat shock...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.