Higher levels of heat shock proteins in longer-lived mammals and birds.

doi:10.1016/j.mad.2011.06.002

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Article

Higher levels of heat shock proteins in longer-lived mammals and birds.

Mechanisms of ageing and development - 1 Jan 2000

Salway Kurtis D, Gallagher Emily J, Page Melissa M, Stuart Jeffrey A

Abstract excerpt

Cellular stress resistance is generally associated with longevity, but the mechanisms underlying this phenotype are not clear. In invertebrate models there is a clear role for heat shock proteins (Hsps) and organelle-specific unfolded protein responses (UPR) in longevity. However, this has not been demonstrated in vertebrates. Some Hsp amino acid sequences are highly conserved amongst mammals and birds. We used...

Topics

Animals
Cattle
Dogs
Endoplasmic Reticulum Chaperone BiP
Finches
Gene Expression Regulation
Guinea Pigs
Heat-Shock Proteins
Longevity
Mice
Mutation
Organ Specificity
Rabbits
Rats
Sheep
Species Specificity
Swine

Source

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Identifiers

PMID: 21703294
DOI: 10.1016/j.mad.2011.06.002

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