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Higher levels of heat shock proteins in longer-lived mammals and birds.

Mechanisms of ageing and development - 1 Jan 2000

Salway Kurtis D, Gallagher Emily J, Page Melissa M, Stuart Jeffrey A

Abstract excerpt

Cellular stress resistance is generally associated with longevity, but the mechanisms underlying this phenotype are not clear. In invertebrate models there is a clear role for heat shock proteins (Hsps) and organelle-specific unfolded protein responses (UPR) in longevity. However, this has not been demonstrated in vertebrates. Some Hsp amino acid sequences are highly conserved amongst mammals and birds. We used...

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PMID: 21703294
DOI: 10.1016/j.mad.2011.06.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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