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The cytoprotective sequestration activity of small heat shock proteins is evolutionarily conserved

7 Sept 2022

Abstract excerpt

The chaperone-mediated sequestration of misfolded proteins into inclusions is a pivotal cellular strategy to maintain proteostasis in Saccharomyces cerevisiae, executed by small heat shock proteins (sHsps) Hsp42 and Btn2. Direct homologs of Hsp42 and Btn2 are absent in other organisms, questioning whether sequestration represents a conserved proteostasis strategy and, if so, which factors are involved. We...

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PMID: 36069810
DOI: 10.1083/jcb.202202149

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