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Article

Search for novel stress-responsive protein components using a yeast mutant lacking two cytosolic Hsp70 genes, SSA1 and SSA2.

Molecules and cells - 30 Jun 2006

Matsumoto Rena, Rakwal Randeep, Agrawal Ganesh Kumar, Jung Young-Ho, Jwa Nam-Soo, Yonekura Masami, Iwahashi Hitoshi, Akama Kuniko

Abstract excerpt

Heat shock proteins (Hsp) 70 are a ubiquitous family of molecular chaperones involved in many cellular processes. A yeast strain, ssa1/2, with two functionally redundant cytosolic Hsp70s (SSA1 and SSA2) deleted shows thermotolerance comparable to mildly heat-shocked wild type yeast, as well as increased protein synthesis and ubiquitin-proteasome protein degradation. Since mRNA abundance does not always correlate...

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PMID: 16819301

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