Article
Hsp12 is an intrinsically unstructured stress protein that folds upon membrane association and modulates membrane function.
Molecular cell - 27 Aug 2010
Welker Sylvia, Rudolph Birgit, Frenzel Elke, Hagn Franz, Liebisch Gerhard, Schmitz Gerd, Scheuring Johannes, Kerth Andreas, Blume Alfred, Weinkauf Sevil, Haslbeck Martin, Kessler Horst, Buchner Johannes
Abstract excerpt
Hsp12 of S. cerevisiae is upregulated several 100-fold in response to stress. Our phenotypic analysis showed that this protein is important for survival of a variety of stress conditions, including high temperature. In the absence of Hsp12, we observed changes in cell morphology under stress conditions. Surprisingly, in the cell, Hsp12 exists both as a soluble cytosolic protein and associated to the plasma...
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