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Article

Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents.

Proceedings of the National Academy of Sciences of the United States of America - 14 Aug 2012

Tóth Balázs, Csanády László

Abstract excerpt

The Ca(2+)-permeable cation channel transient receptor potential melastatin 2 (TRPM2) plays a key role in pathogen-evoked phagocyte activation, postischemic neuronal apoptosis, and glucose-evoked insulin secretion, by linking these cellular responses to oxidative stress. TRPM2 channels are coactivated by binding of intracellular ADP ribose and Ca(2+) to distinct cytosolically accessible sites on the channels....

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Topics

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Share to Adenosine Diphosphate Ribose
Share to Cations
Share to Cell Membrane Permeability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphatidylinositol 4,5-Diphosphate

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Source

Open in PubMed Open full text

Identifiers

PMID: 22847436
DOI: 10.1073/pnas.1204702109
PMCID: PMC3421201

Genes

TRPM2
PIP
TRPM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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