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Article

Conserved cysteine residues in the pore region are obligatory for human TRPM2 channel function.

American journal of physiology. Cell physiology - 1 Nov 2006

Mei Zhu-Zhong, Mao Hong-Ju, Jiang Lin-Hua

Abstract excerpt

TRPM2 proteins belong to the melastatin-related transient receptor potential or TRPM subfamily and form Ca(2+)-permeable cationic channels activated by intracellular adenosine diphosphoribose (ADPR). The TRPM2 channel subunit, like all its close relatives, is structurally homologous to the well-characterized voltage-gated potassium channel subunits, each containing six transmembrane segments and a putative pore...

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Source

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Identifiers

PMID: 16822940
DOI: 10.1152/ajpcell.00606.2005
PMCID: PMC1634803

Genes

TRPM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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