Article
Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels.
The Journal of biological chemistry - 18 Feb 2005
Perraud Anne-Laure, Takanishi Christina L, Shen Betty, Kang Shin, Smith Megan K, Schmitz Carsten, Knowles Heather M, Ferraris Dana, Li Weixing, Zhang Jie, Stoddard Barry L, Scharenberg Andrew M
Abstract excerpt
TRPM2 is a member of the transient receptor potential melastatin-related (TRPM) family of cation channels, which possesses both ion channel and ADP-ribose hydrolase functions. TRPM2 has been shown to gate in response to oxidative and nitrosative stresses, but the mechanism through which TRPM2 gating is induced by these types of stimuli is not clear. Here we show through structure-guided mutagenesis that TRPM2...
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