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Article

Selective profiling of N- and C-terminal nucleotide-binding sites in a TRPM2 channel.

The Journal of general physiology - 4 May 2020

Tóth Balázs, Iordanov Iordan, Csanády László

Abstract excerpt

Transient receptor potential melastatin 2 (TRPM2) is a homotetrameric Ca2+-permeable cation channel important for the immune response, body temperature regulation, and insulin secretion, and is activated by cytosolic Ca2+ and ADP ribose (ADPR). ADPR binds to two distinct locations, formed by large N- and C-terminal cytosolic domains, respectively, of the channel protein. In invertebrate TRPM2 channels, the...

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Share to Adenosine Diphosphate Ribose
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32211872
DOI: 10.1085/jgp.201912533
PMCID: PMC7201885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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