Article
Regulation of the transient receptor potential channel TRPM2 by the Ca2+ sensor calmodulin.
The Journal of biological chemistry - 7 Apr 2006
Tong Qin, Zhang Wenyi, Conrad Kathleen, Mostoller Kate, Cheung Joseph Y, Peterson Blaise Z, Miller Barbara A
Abstract excerpt
TRPM2, a member of the transient receptor potential (TRP) superfamily, is a Ca(2+)-permeable channel activated by oxidative stress or tumor necrosis factoralpha involved in susceptibility to cell death. TRPM2 activation is dependent on the level of intracellular Ca(2+). We explored whether calmodulin (CaM) is the Ca(2+) sensor for TRPM2. HEK 293T cells were transfected with TRPM2 and wild type CaM or mutant CaM...
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