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Article

Intracellular calcium activates TRPM2 and its alternative spliced isoforms.

Proceedings of the National Academy of Sciences of the United States of America - 28 Apr 2009

Du Jianyang, Xie Jia, Yue Lixia

Abstract excerpt

Melastatin-related transient receptor potential channel 2 (TRPM2) is a Ca(2+)-permeable, nonselective cation channel that is involved in oxidative stress-induced cell death and inflammation processes. Although TRPM2 can be activated by ADP-ribose (ADPR) in vitro, it was unknown how TRPM2 is gated in vivo. Moreover, several alternative spliced isoforms of TRPM2 identified recently are insensitive to ADPR, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19372375
DOI: 10.1073/pnas.0811725106
PMCID: PMC2678461

Genes

TRPM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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