Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate.

The EMBO journal - 8 Feb 2006

Nilius Bernd, Mahieu Frank, Prenen Jean, Janssens Annelies, Owsianik Grzegorz, Vennekens Rudi, Voets Thomas

Abstract excerpt

Transient receptor potential (TRP) channel, melastatin subfamily (TRPM)4 is a Ca2+-activated monovalent cation channel that depolarizes the plasma membrane and thereby modulates Ca2+ influx through Ca2+-permeable pathways. A typical feature of TRPM4 is its rapid desensitization to intracellular Ca2+ ([Ca2+]i). Here we show that phosphatidylinositol 4,5-biphosphate (PIP2) counteracts desensitization to [Ca2+]i in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Cricetinae
Share to Cricetulus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ion Channel Gating

Share to Patch-Clamp Techniques

Share to Phosphatidylinositol 4,5-Diphosphate

Share to TRPM Cation Channels

Share to Type C Phospholipases

Source

Open in PubMed Open full text

Identifiers

PMID: 16424899
DOI: 10.1038/sj.emboj.7600963
PMCID: PMC1383543

Genes

TRPM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate.PMID 16424899Read ↗

Negatively charged amino acids near and in transient receptor potential (TRP) domain of TRPM4 channel are one determinant of its Ca2+ sensitivity.Semantic proximity Read ↗

PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain.Semantic proximity Read ↗

Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4.Semantic proximity Read ↗

Dual regulation of voltage-gated calcium channels by PtdIns(4,5)P2.Semantic proximity Read ↗

A molecular determinant of phosphoinositide affinity in mammalian TRPV channels.Semantic proximity Read ↗

TRPM4.Semantic proximity Read ↗

PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents.Semantic proximity Read ↗

Heat- and PIP2-dependent TRPM4 activity underlies mutually exclusive human diseases.Semantic proximity Read ↗

An essential role of PI(4,5)P₂ for maintaining the activity of the transient receptor potential canonical (TRPC)4β.Semantic proximity Read ↗

TRPC4- and TRPC4-containing channels.Semantic proximity Read ↗

Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents.Semantic proximity Read ↗

Voltage- and temperature-dependent activation of TRPV3 channels is potentiated by receptor-mediated PI(4,5)P2 hydrolysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.