Article
PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain.
Nature neuroscience - 1 May 2005
Rohács Tibor, Lopes Coeli M B, Michailidis Ioannis, Logothetis Diomedes E
Abstract excerpt
The subjective feeling of cold is mediated by the activation of TRPM8 channels in thermoreceptive neurons by cold or by cooling agents such as menthol. Here, we demonstrate a central role for phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) in the activation of recombinant TRPM8 channels by both cold and menthol. Moreover, we show that Ca(2+) influx through these channels activates a Ca(2+)-sensitive...
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