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Article

Naturally evolved G protein-coupled receptors adopt metastable conformations.

Proceedings of the National Academy of Sciences of the United States of America - 14 Aug 2012

Chen Kuang-Yui Michael, Zhou Fuguo, Fryszczyn Bartlomiej G, Barth Patrick

Abstract excerpt

A wide range of membrane receptors signal through conformational changes, and the resulting protein conformational flexibility often hinders their structural studies. Because the determinants of membrane receptor conformational stability are still poorly understood, identifying a minimal set of perturbations stabilizing a membrane protein in a given conformation remains a major challenge in membrane protein...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22847407
DOI: 10.1073/pnas.1205512109
PMCID: PMC3421219

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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