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Article

Structure of a beta1-adrenergic G-protein-coupled receptor.

Nature - 24 Jul 2008

Warne Tony, Serrano-Vega Maria J, Baker Jillian G, Moukhametzianov Rouslan, Edwards Patricia C, Henderson Richard, Leslie Andrew G W, Tate Christopher G, Schertler Gebhard F X

Abstract excerpt

G-protein-coupled receptors have a major role in transmembrane signalling in most eukaryotes and many are important drug targets. Here we report the 2.7 A resolution crystal structure of a beta(1)-adrenergic receptor in complex with the high-affinity antagonist cyanopindolol. The modified turkey (Meleagris gallopavo) receptor was selected to be in its antagonist conformation and its thermostability improved by...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18594507
DOI: 10.1038/nature07101
PMCID: PMC2923055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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