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Article

Structural insights into conformational stability of wild-type and mutant beta1-adrenergic receptor.

Biophysical journal - 21 Jul 2010

Balaraman Gouthaman S, Bhattacharya Supriyo, Vaidehi Nagarajan

Abstract excerpt

Recent experiments to derive a thermally stable mutant of turkey beta-1-adrenergic receptor (beta1AR) have shown that a combination of six single point mutations resulted in a 20 degrees C increase in thermal stability in mutant beta1AR. Here we have used the all-atom force-field energy function to calculate a stability score to detect stabilizing point mutations in G-protein coupled receptors. The calculated...

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Identifiers

PMID: 20643076
DOI: 10.1016/j.bpj.2010.04.075
PMCID: PMC2905111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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