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Article

Co-evolving stability and conformational homogeneity of the human adenosine A2a receptor.

Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2008

Magnani Francesca, Shibata Yoko, Serrano-Vega Maria J, Tate Christopher G

Abstract excerpt

Structural studies on mammalian integral membrane proteins have long been hampered by their instability in detergent. This is particularly true for the agonist conformation of G protein-coupled receptors (GPCRs), where it is thought that the movement of helices that occurs upon agonist binding re...

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Identifiers

PMID: 18664584
DOI: 10.1073/pnas.0804396105
PMCID: PMC2504806

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18664584-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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