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Article

Engineering an ultra-thermostable β(1)-adrenoceptor.

Journal of molecular biology - 28 Oct 2011

Miller Jennifer L, Tate Christopher G

Abstract excerpt

Conformational thermostabilisation of G-protein-coupled receptors is a successful strategy for their structure determination. The thermostable mutants tolerate short-chain detergents, such as octylglucoside and nonylglucoside, which are ideal for crystallography, and in addition, the receptors are preferentially in a single conformational state. The first thermostabilised receptor to have its structure determined...

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Identifiers

PMID: 21907721
DOI: 10.1016/j.jmb.2011.08.057
PMCID: PMC3819908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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