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Article

Regulation of protein function by native metastability.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2000

Lee C, Park S H, Lee M Y, Yu M H

Abstract excerpt

In common globular proteins, the native form is in its most stable state. In contrast, each native form exists in a metastable state in inhibitory serpins (serine protease inhibitors) and some viral membrane fusion proteins. Metastability in these proteins is critical to their biological functions. Mutational analyses and structural examination have previously revealed unusual interactions, such as side-chain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10884404
DOI: 10.1073/pnas.97.14.7727
PMCID: PMC16612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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