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Article

The role of MAP4K3 in lifespan regulation of Caenorhabditis elegans.

Biochemical and biophysical research communications - 24 Aug 2012

Khan Maruf H, Hart Matthew J, Rea Shane L

Abstract excerpt

The TOR pathway is a kinase signaling pathway that regulates cellular growth and proliferation in response to nutrients and growth factors. TOR signaling is also important in lifespan regulation - when this pathway is inhibited, either naturally, by genetic mutation, or by pharmacological means, lifespan is extended. MAP4K3 is a Ser/Thr kinase that has recently been found to be involved in TOR activation....

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Identifiers

PMID: 22846570
DOI: 10.1016/j.bbrc.2012.07.113

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