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Article

A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.

Molecular and cellular biology - 1 Jan 2010

Cully Megan, Genevet Alice, Warne Patricia, Treins Caroline, Liu Tao, Bastien Julie, Baum Buzz, Tapon Nic, Leevers Sally J, Downward Julian

Abstract excerpt

The target of rapamycin (TOR) complex 1 (TORC1) signaling pathway is a critical regulator of translation and cell growth. To identify novel components of this pathway, we performed a kinome-wide RNA interference (RNAi) screen in Drosophila melanogaster S2 cells. RNAi targeting components of the p38 stress-activated kinase cascade prevented the cell size increase elicited by depletion of the TOR negative regulator...

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Source

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Identifiers

PMID: 19917724
DOI: 10.1128/MCB.00688-09
PMCID: PMC2798466

Genes

TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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