Article
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans.
PLoS genetics - 1 Feb 2008
Hansen Malene, Chandra Abha, Mitic Laura L, Onken Brian, Driscoll Monica, Kenyon Cynthia
Abstract excerpt
In many organisms, dietary restriction appears to extend lifespan, at least in part, by down-regulating the nutrient-sensor TOR (Target Of Rapamycin). TOR inhibition elicits autophagy, the large-scale recycling of cytoplasmic macromolecules and organelles. In this study, we asked whether autophagy might contribute to the lifespan extension induced by dietary restriction in C. elegans. We find that dietary...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.