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Article

Hypertension impairs myocardin function: a novel mechanism facilitating arterial remodelling.

Cardiovascular research - 1 Oct 2012

Pfisterer Larissa, Feldner Anja, Hecker Markus, Korff Thomas

Abstract excerpt

AIMS: Hypertension evokes detrimental changes in the arterial vessel wall that facilitate stiffening and thus lead to a further rise in mean blood pressure, eventually causing heart failure. The underlying pathophysiological remodelling process is elicited by an increase in wall stress (WS) and is strictly dependent on the activation of vascular smooth muscle cells (SMC). However, it remains unclear as to why...

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Source

Identifiers

PMID: 22843699
DOI: 10.1093/cvr/cvs247

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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