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Article

Ageing causes an aortic contractile dysfunction phenotype by targeting the expression of members of the extracellular signal-regulated kinase pathway.

Journal of cellular and molecular medicine - 1 Mar 2022

Nicholson Christopher J, Xing Yi, Lee Sophie, Liang Stephanie, Mohan Shivani, O'Rourke Caitlin, Kang Joshua, Morgan Kathleen G

Abstract excerpt

The extracellular signal-regulated kinase (ERK) pathway is a well-known regulator of vascular smooth muscle cell proliferation, but it also serves as a regulator of caldesmon, which negatively regulates vascular contractility. This study examined whether aortic contractile function requires ERK activation and if this activation is regulated by ageing. Biomechanical experiments revealed that contractile responses...

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PMID: 35181997
DOI: 10.1111/jcmm.17118
PMCID: PMC8899171

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