Article
The N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97.
The Journal of biological chemistry - 4 Dec 2015
Trusch Franziska, Matena Anja, Vuk Maja, Koerver Lisa, Knævelsrud Helene, Freemont Paul S, Meyer Hemmo, Bayer Peter
Abstract excerpt
Valosin-containing protein/p97 is an ATP-driven protein segregase that cooperates with distinct protein cofactors to control various aspects of cellular homeostasis. Mutations at the interface between the regulatory N-domain and the first of two ATPase domains (D1 and D2) deregulate the ATPase activity and cause a multisystem degenerative disorder, inclusion body myopathy associated with Paget disease of bone and...
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