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Article

Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease.

Stem cell reports - 9 May 2017

Friesen Max, Camahort Raymond, Lee Youn-Kyoung, Xia Fang, Gerszten Robert E, Rhee Eugene P, Deo Rahul C, Cowan Chad A

Abstract excerpt

The striking rise of obesity-related metabolic disorders has focused attention on adipocytes as critical mediators of disease phenotypes. To better understand the role played by excess adipose in metabolic dysfunction it is crucial to decipher the transcriptional underpinnings of the low-grade adipose inflammation characteristic of diseases such as type 2 diabetes. Through employing a comparative transcriptomics...

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Identifiers

PMID: 28416283
DOI: 10.1016/j.stemcr.2017.03.014
PMCID: PMC5425619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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