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Article

Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein.

The Journal of biological chemistry - 14 Sept 2012

Richter Kathleen, Burch Lauranell, Chao Frank, Henke David, Jiang Chuancang, Daly Janssen, Zhao Ming-Lang, Kissling Grace, Diaz Marilyn

Abstract excerpt

We recently identified a novel germinal center GTPase, SLIP-GC, that localizes to replication factories in B cells and that, when reduced, induces DNA breaks in lymphoma B cell lines in an activation-induced deaminase (AID)-dependent manner. Herein, we generated mice deficient in SLIP-GC and examined the impact of SLIP-GC deficiency in immunoglobulin hypermutation and class switch recombination, both...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22833677
DOI: 10.1074/jbc.M112.340661
PMCID: PMC3442519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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