Article
SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation.
Proceedings of the National Academy of Sciences of the United States of America - 8 May 2018
Thientosapol Eddy Sanchai, Bosnjak Daniel, Durack Timothy, Stevanovski Igor, van Geldermalsen Michelle, Holst Jeff, Jahan Zeenat, Shepard Caitlin, Weninger Wolfgang, Kim Baek, Brink Robert, Jolly Christopher J
Abstract excerpt
Activation-induced deaminase (AID) initiates hypermutation of Ig genes in activated B cells by converting C:G into U:G base pairs. G1-phase variants of uracil base excision repair (BER) and mismatch repair (MMR) then deploy translesion polymerases including REV1 and Pol η, which exacerbates mutation. dNTP paucity may contribute to hypermutation, because dNTP levels are reduced in G1 phase to inhibit viral...
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