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Article

DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation.

Immunity - 1 Nov 2000

Bross L, Fukita Y, McBlane F, Démollière C, Rajewsky K, Jacobs H

Abstract excerpt

How rearranged immunoglobulin (Ig) genes are further diversified by somatic hypermutation is unknown. Using VDJ passenger Ig heavy chain (IgH) knockin mouse strains, we now demonstrate a high frequency of DNA double-strand breaks (DSBs) in the targeted VDJ passenger gene of germinal center (GC) B cells. These DSBs parallel the distribution of mutations in the targeted hypermutation domain and are found...

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PMID: 11114372
DOI: 10.1016/s1074-7613(00)00059-5

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