Article
Probing immunoglobulin gene hypermutation with microsatellites suggests a nonreplicative short patch DNA synthesis process.
Immunity - 1 Aug 1998
Bertocci B, Quint L, Delbos F, Garcia C, Reynaud C A, Weill J C
Abstract excerpt
As the rate of Ig gene hypermutation approximates the level of nucleotide discrimination of DNA polymerases (10(-3) to 10(-4)), a local inhibition of proofreading and mismatch repair during semiconservative replication could generate the mutations introduced by the process. To address this questi...
Topics
- Animals
- B-Lymphocytes
- DNA
- DNA Probes
- DNA Repair
- DNA Replication
- DNA-Directed DNA Polymerase
- Frameshift Mutation
- Genes, Immunoglobulin
- Immunoglobulin Variable Region
- Immunoglobulin kappa-Chains
- Mice