Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activated Ras protein accelerates cell cycle progression to perturb Madin-Darby canine kidney cystogenesis.

The Journal of biological chemistry - 14 Sept 2012

Sakurai Atsuro, Matsuda Michiyuki, Kiyokawa Etsuko

Abstract excerpt

In a number of human cancer cells, K-RAS is frequently mutated and activated constitutively, culminating in the induction of continuous cell growth, a hallmark of cancer cells. It is still unclear, however, how the mutated K-RAS induces morphological abnormalities in cancerous tissues. To investigate the mechanism underlying the K-RAS-induced morphological changes, we utilized an auxin-dependent protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma
Share to Cell Separation
Share to Dogs

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fluorescence Resonance Energy Transfer

Share to Kidney

Share to Phosphatidylinositol 3-Kinases

Share to raf Kinases

Share to ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22829590
DOI: 10.1074/jbc.M112.377804
PMCID: PMC3442505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activated Ras protein accelerates cell cycle progression to perturb Madin-Darby canine kidney cystogenesis.PMID 22829590Read ↗

Modulation of Oncogenic KRAS Signaling by Branched Actin-driven Cell Membrane ProtrusionsSemantic proximity Read ↗

Modulation of Oncogenic KRAS Signaling by Branched Actin-driven Cell Membrane ProtrusionsSemantic proximity Read ↗

Constitutively active mitogen-activated protein kinase kinase MEK1 disrupts morphogenesis and induces an invasive phenotype in Madin-Darby canine kidney epithelial cells.Semantic proximity Read ↗

Cell polarity as a regulator of cancer cell behavior plasticity.Semantic proximity Read ↗

K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc.Semantic proximity Read ↗

Epithelial to mesenchymal transition in Madin-Darby canine kidney cells is accompanied by down-regulation of Smad3 expression, leading to resistance to transforming growth factor-beta-induced growth arrest.Semantic proximity Read ↗

Constitutively active mutant of the mitogen-activated protein kinase kinase MEK1 induces epithelial dedifferentiation and growth inhibition in madin-darby canine kidney-C7 cells.Semantic proximity Read ↗

Establishing epithelial glandular polarity: interlinked roles for ARF6, Rac1, and the matrix microenvironmentSemantic proximity Read ↗

An apicobasal gradient of Rac activity determines protrusion form and position.Semantic proximity Read ↗

Polarity, cell division, and out-of-equilibrium dynamics control the growth of epithelial structures.Semantic proximity Read ↗

Oncogenic KRas-induced Increase in Fluid-phase Endocytosis is Dependent on N-WASP and is Required for the Formation of Pancreatic Preneoplastic Lesions.Semantic proximity Read ↗

Multilayering and loss of apical polarity in MDCK cells transformed with viral K-ras.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.