Article
Activated Ras protein accelerates cell cycle progression to perturb Madin-Darby canine kidney cystogenesis.
The Journal of biological chemistry - 14 Sept 2012
Sakurai Atsuro, Matsuda Michiyuki, Kiyokawa Etsuko
Abstract excerpt
In a number of human cancer cells, K-RAS is frequently mutated and activated constitutively, culminating in the induction of continuous cell growth, a hallmark of cancer cells. It is still unclear, however, how the mutated K-RAS induces morphological abnormalities in cancerous tissues. To investigate the mechanism underlying the K-RAS-induced morphological changes, we utilized an auxin-dependent protein...
Topics
- Animals
- Apoptosis
- Carcinoma
- Cell Proliferation
- Cell Separation
- Dogs
- Fluorescence Resonance Energy Transfer
- Gene Expression Regulation, Neoplastic
- Humans
- Kidney
- Models, Genetic