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Establishing epithelial glandular polarity: interlinked roles for ARF6, Rac1, and the matrix microenvironment

12 Oct 2012

Abstract excerpt

Epithelial cysts comprise the structural units of the glandular epithelium. Although glandular inversion in epithelial tumors is thought to be a potential mechanism for the establishment of metastatic disease, little is known about the morphogenic cues and signaling pathways that govern glandular polarity and organization. Using organotypic cultures of Madin-Darby canine kidney cells in reconstituted basement...

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PMID: 23051733
DOI: 10.1091/mbc.e12-03-0246

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