Article
Polarity, cell division, and out-of-equilibrium dynamics control the growth of epithelial structures.
The Journal of cell biology - 28 Oct 2013
Cerruti Benedetta, Puliafito Alberto, Shewan Annette M, Yu Wei, Combes Alexander N, Little Melissa H, Chianale Federica, Primo Luca, Serini Guido, Mostov Keith E, Celani Antonio, Gamba Andrea
Abstract excerpt
The growth of a well-formed epithelial structure is governed by mechanical constraints, cellular apico-basal polarity, and spatially controlled cell division. Here we compared the predictions of a mathematical model of epithelial growth with the morphological analysis of 3D epithelial structures. In both in vitro cyst models and in developing epithelial structures in vivo, epithelial growth could take place close...
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