Article
Constitutively active mutant of the mitogen-activated protein kinase kinase MEK1 induces epithelial dedifferentiation and growth inhibition in madin-darby canine kidney-C7 cells.
The Journal of biological chemistry - 25 Apr 1997
Schramek H, Feifel E, Healy E, Pollack V
Abstract excerpt
Overexpression of a constitutively active mitogen-activated protein kinase kinase (MAPKK or MEK) induces neuronal differentiation in adrenal pheochromocytoma 12 cells but transformation in fibroblasts. In the present study, we used a constitutively active MAPK/extracellular signal-regulated kinas...
Topics
- Animals
- Antigens, Differentiation
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Differentiation
- Cell Division
- Dogs
- Enzyme Inhibitors
- Epithelial Cells
- Flavonoids
- Kidney
- MAP Kinase Kinase 1
- Mesoderm
- Mitogen-Activated Protein Kinase 1
- Mitogen-Activated Protein Kinase 3