Oncogenic KRas-induced Increase in Fluid-phase Endocytosis is Dependent on N-WASP and is Required for the Formation of Pancreatic Preneoplastic Lesions.

doi:10.1016/j.ebiom.2016.12.013

Article

Oncogenic KRas-induced Increase in Fluid-phase Endocytosis is Dependent on N-WASP and is Required for the Formation of Pancreatic Preneoplastic Lesions.

EBioMedicine - 1 Feb 2017

Lubeseder-Martellato Clara, Alexandrow Katharina, Hidalgo-Sastre Ana, Heid Irina, Boos Sophie Luise, Briel Thomas, Schmid Roland M, Siveke Jens T

Abstract excerpt

Fluid-phase endocytosis is a homeostatic process with an unknown role in tumor initiation. The driver mutation in pancreatic ductal adenocarcinoma (PDAC) is constitutively active KRasG12D, which induces neoplastic transformation of acinar cells through acinar-to-ductal metaplasia (ADM). We have previously shown that KRasG12D-induced ADM is dependent on RAC1 and EGF receptor (EGFR) by a not fully clarified...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Oncogenic KRas-induced Increase in Fluid-phase Endocytosis is Dependent on N-WASP and is Required for the Formation of Pancreatic Preneoplastic Lesions.

Abstract excerpt

Topics

Related research