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Article

An apicobasal gradient of Rac activity determines protrusion form and position.

Nature communications - 19 May 2017

Couto Africa, Mack Natalie Ann, Favia Lucrezia, Georgiou Marios

Abstract excerpt

Each cell within a polarized epithelial sheet must align and correctly position a wide range of subcellular structures, including actin-based dynamic protrusions. Using in vivo inducible transgenes that can sense or modify Rac activity, we demonstrate an apicobasal gradient of Rac activity that is required to correctly form and position distinct classes of dynamic protrusion along the apicobasal axis of the cell....

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Identifiers

PMID: 28524861
DOI: 10.1038/ncomms15385
PMCID: PMC5454455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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