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Article

K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc.

The Journal of cell biology - 23 Jul 2012

Magudia Kirti, Lahoz Aurelia, Hall Alan

Abstract excerpt

KRAS, BRAF, and PI3KCA are the most frequently mutated oncogenes in human colon cancer. To explore their effects on morphogenesis, we used the colon cancer-derived cell line Caco-2. When seeded in extracellular matrix, individual cells proliferate and generate hollow, polarized cysts. The express...

Topics

Caco-2 Cells
Cell Polarity
Cell Proliferation
Extracellular Matrix
Extracellular Signal-Regulated MAP Kinases
Humans
Mutation
Nuclear Proteins
Oncogenes
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins c-myc
Proto-Oncogene Proteins p21(ras)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tight Junctions

Transcription Factors

Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 22826122
DOI: 10.1083/jcb.201202108
PMCID: PMC3410422

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-22826122-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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