Article
Unidirectional peristaltic movement in multisite drug binding pockets of AcrB from molecular dynamics simulations.
Molecular bioSystems - 1 Oct 2012
Feng Zhiwei, Hou Tingjun, Li Youyong
Abstract excerpt
Tripartite complex AcrB-ToIC, the major efflux system in Escherichia coli, is the principal multidrug transporter in Gram-negative bacteria, which is important in antibiotic drug tolerance. AcrB is a homotrimer that acts as a tripartite complex with the outer membrane channel ToIC and the membrane fusion protein AcrA. Recently, the crystal structures of AcrB bound to the high-molecular-mass drugs rifampicin and...
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