Article
AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity.
Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2015
Blair Jessica M A, Bavro Vassiliy N, Ricci Vito, Modi Niraj, Cacciotto Pierpaolo, Kleinekathӧfer Ulrich, Ruggerone Paolo, Vargiu Attilio V, Baylay Alison J, Smith Helen E, Brandon Yvonne, Galloway David, Piddock Laura J V
Abstract excerpt
The incidence of multidrug-resistant bacterial infections is increasing globally and the need to understand the underlying mechanisms is paramount to discover new therapeutics. The efflux pumps of Gram-negative bacteria have a broad substrate range and transport antibiotics out of the bacterium, conferring intrinsic multidrug resistance (MDR). The genomes of pre- and posttherapy MDR clinical isolates of...
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