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Article

Extramembrane central pore of multidrug exporter AcrB in Escherichia coli plays an important role in drug transport.

The Journal of biological chemistry - 30 Jan 2004

Murakami Satoshi, Tamura Norihisa, Saito Asami, Hirata Takahiro, Yamaguchi Akihito

Abstract excerpt

We previously reported the crystal structure of the major multidrug exporter AcrB in Escherichia coli (Murakami, S., Nakashima, R., Yamashita, E., and Yamaguchi, A. (2002) Nature 419, 587-593). The extramembrane headpiece of the AcrB trimer contains a central pore composed of three alpha-helices. Each pore helix belongs to a different monomer. In this study, we constructed cysteine-scanning mutants as to the...

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PMID: 14576158
DOI: 10.1074/jbc.M308893200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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