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Article

Allosteric drug transport mechanism of multidrug transporter AcrB.

Nature communications - 29 Jun 2021

Tam Heng-Keat, Foong Wuen Ee, Oswald Christine, Herrmann Andrea, Zeng Hui, Pos Klaas M

Abstract excerpt

Gram-negative bacteria maintain an intrinsic resistance mechanism against entry of noxious compounds by utilizing highly efficient efflux pumps. The E. coli AcrAB-TolC drug efflux pump contains the inner membrane H+/drug antiporter AcrB comprising three functionally interdependent protomers, cycling consecutively through the loose (L), tight (T) and open (O) state during cooperative catalysis. Here, we present 13...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34188038
DOI: 10.1038/s41467-021-24151-3
PMCID: PMC8242077

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