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Article

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket.

Nature - 27 Nov 2011

Nakashima Ryosuke, Sakurai Keisuke, Yamasaki Seiji, Nishino Kunihiko, Yamaguchi Akihito

Abstract excerpt

AcrB and its homologues are the principal multidrug transporters in Gram-negative bacteria and are important in antibiotic drug tolerance. AcrB is a homotrimer that acts as a tripartite complex with the outer membrane channel TolC and the membrane fusion protein AcrA. Minocycline and doxorubicin have been shown to bind to the phenylalanine cluster region of the binding monomer. Here we report the crystal...

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Identifiers

PMID: 22121023
DOI: 10.1038/nature10641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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