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Article

Conformational flexibility in the multidrug efflux system protein AcrA.

Structure (London, England : 1993) - 1 Mar 2006

Mikolosko Jonathan, Bobyk Kostyantyn, Zgurskaya Helen I, Ghosh Partho

Abstract excerpt

Intrinsic resistance to multiple drugs in many gram-negative bacterial pathogens is conferred by resistance nodulation cell division efflux pumps, which are composed of three essential components as typified by the extensively characterized Escherichia coli AcrA-AcrB-TolC system. The inner membrane drug:proton antiporter AcrB and the outer membrane channel TolC export chemically diverse compounds out of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16531241
DOI: 10.1016/j.str.2005.11.015
PMCID: PMC1997295

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Conformational flexibility in the multidrug efflux system protein AcrA.PMID 16531241Read ↗

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