Article
Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB.
Nature communications - 4 Nov 2020
Reading Eamonn, Ahdash Zainab, Fais Chiara, Ricci Vito, Wang-Kan Xuan, Grimsey Elizabeth, Stone Jack, Malloci Giuliano, Lau Andy M, Findlay Heather, Konijnenberg Albert, Booth Paula J, Ruggerone Paolo, Vargiu Attilio V, Piddock Laura J V, Politis Argyris
Abstract excerpt
Resistance-nodulation-division efflux pumps play a key role in inherent and evolved multidrug resistance in bacteria. AcrB, a prototypical member of this protein family, extrudes a wide range of antimicrobial agents out of bacteria. Although high-resolution structures exist for AcrB, its conformational fluctuations and their putative role in function are largely unknown. Here, we determine these structural...
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