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Article

Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump.

mBio - 2 Jun 2020

Grimsey Elizabeth M, Fais Chiara, Marshall Robert L, Ricci Vito, Ciusa Maria Laura, Stone Jack W, Ivens Alasdair, Malloci Giuliano, Ruggerone Paolo, Vargiu Attilio V, Piddock Laura J V

Abstract excerpt

Efflux is an important mechanism in Gram-negative bacteria conferring multidrug resistance. Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics. Chlorpromazine and amitriptyline have been shown to behave as efflux inhibitors. However, their mode of action is poorly understood. Exposure of Salmonella enterica serovar Typhimurium and Escherichia coli to...

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Identifiers

PMID: 32487753
DOI: 10.1128/mBio.00465-20
PMCID: PMC7267879

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