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Article

Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition.

Nature communications - 9 Jan 2018

Zwama Martijn, Yamasaki Seiji, Nakashima Ryosuke, Sakurai Keisuke, Nishino Kunihiko, Yamaguchi Akihito

Abstract excerpt

AcrB is the major multidrug exporter in Escherichia coli. Although several substrate-entrances have been identified, the specificity of these various transport paths remains unclear. Here we present evidence for a substrate channel (channel 3) from the central cavity of the AcrB trimer, which is connected directly to the deep pocket without first passing the switch-loop and the proximal pocket . Planar aromatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29317622
DOI: 10.1038/s41467-017-02493-1
PMCID: PMC5760665

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