Article
Effect of the F610A mutation on substrate extrusion in the AcrB transporter: explanation and rationale by molecular dynamics simulations.
Journal of the American Chemical Society - 20 Jul 2011
Vargiu Attilio V, Collu Francesca, Schulz Robert, Pos Klaas M, Zacharias Martin, Kleinekathöfer Ulrich, Ruggerone Paolo
Abstract excerpt
The tripartite efflux pump AcrAB-TolC is responsible for the intrinsic and acquired multidrug resistance in Escherichia coli. Its active part, the homotrimeric transporter AcrB, is in charge of the selective binding of substrates and energy transduction. The mutation F610A has been shown to significantly reduce the minimum inhibitory concentration of doxorubicin and many other substrates, although F610 does not...
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