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Article

Dissecting the function of a protruding loop in AcrB trimerization.

Journal of biomolecular structure & dynamics - 1 Apr 2013

Fang Jun, Yu Linliang, Wu Maria, Wei Yinan

Abstract excerpt

The resistance-nodulation-cell division family multidrug transporter Acriflavine resistance protein B (AcrB) from Eschericha coli is an obligate homotrimer. Approximately, 45% of the inter-subunit interface is contributed by a protruding loop (also referred to as the thumb) and its corresponding binding tunnel in the neighboring subunit. In an earlier study, we have demonstrated that a single Pro to Gly mutation...

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Identifiers

PMID: 22877148
DOI: 10.1080/07391102.2012.703065

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