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Article

Polymorphism in glutamate cysteine ligase catalytic subunit (GCLC) is associated with sulfamethoxazole-induced hypersensitivity in HIV/AIDS patients.

BMC medical genomics - 23 Jul 2012

Wang Danxin, Curtis Amanda, Papp Audrey C, Koletar Susan L, Para Michael F

Abstract excerpt

BACKGROUND: Sulfamethoxazole (SMX) is a commonly used antibiotic for prevention of infectious diseases associated with HIV/AIDS and immune-compromised states. SMX-induced hypersensitivity is an idiosyncratic cutaneous drug reaction with genetic components. Here, we tested association of candidate genes involved in SMX bioactivation and antioxidant defense with SMX-induced hypersensitivity. RESULTS: Seventy seven...

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Share to AIDS-Related Opportunistic Infections
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotyping Techniques

Share to Glutamate-Cysteine Ligase

Share to Glutathione

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Share to Inactivation, Metabolic

Share to Trimethoprim, Sulfamethoxazole Drug Combination

Source

Open in PubMed Open full text

Identifiers

PMID: 22824134
DOI: 10.1186/1755-8794-5-32
PMCID: PMC3418550

Genes

GCLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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