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Article

Evaluation of polymorphisms in the sulfonamide detoxification genes CYB5A and CYB5R3 in dogs with sulfonamide hypersensitivity.

Journal of veterinary internal medicine - 1 Jan 2000

Funk-Keenan J, Sacco J, Wong Y Y Amos, Rasmussen S, Motsinger-Reif A, Trepanier L A

Abstract excerpt

BACKGROUND: Delayed hypersensitivity (HS) reactions to potentiated sulfonamide antimicrobials occur in both dogs and humans, and involve an intermediate hydroxylamine metabolite that is detoxified by cytochrome b(5) and NADH cytochrome b(5) reductase. HYPOTHESIS/OBJECTIVES: We hypothesized that polymorphisms in the genes (CYB5A and CYB5R3) encoding these 2 enzymes would be associated with risk of sulfonamide HS...

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Identifiers

PMID: 22816446
DOI: 10.1111/j.1939-1676.2012.00965.x
PMCID: PMC4474156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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